Wnt4 is required for proper male as well as female sexual development

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Wnt4 is required for proper male as well as female sexual development.

Genes previously implicated in mammalian sexual development have either a male- or female-specific role. The signaling molecule WNT4 has been shown to be important in female sexual development. Lack of Wnt4 gives rise to masculinization of the XX gonad and we showed previously that the role of WNT4 was to inhibit endothelial and steroidogenic cell migration into the developing ovary. Here we sh...

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ژورنال

عنوان ژورنال: Developmental Biology

سال: 2004

ISSN: 0012-1606

DOI: 10.1016/j.ydbio.2004.08.049